Endocrine Abstracts

TSH secreting pituitary adenomas are rare tumours for which the treatment of choice is neurosurgery but in some cases medical treatment with somatostatin analogs (SSA) can lead to a good control of symptoms and shrinkage of the tumour.The objective of this study was to review 30 patients diagnosed with TSH-omas between October 1981–July 2014, followed-up for a median of 43.93 months (1.12–192.11) in our University Hospital from Lyon, France.</p...

Introduction: Silent somatotroph tumours are GH immunoreactive (IR) pituitary tumours without clinical and biological signs of acromegaly. In our series, they represent 16% of all the somatotroph pituitary tumours. The aim of our study was to compare the somatotroph tumours with and without acromegaly to a better characterization of these silent tumours.Materials and methods: Fifty-nine tumours with acromegaly and 21 silent somatotroph tumours were studi...

Introduction: In the era of personalized patient management in acromegaly, transsphenoidal surgery remains a treatment of choice in cases where surgical cure can be expected. In order to better target these patients and to assess the risk of persistence/progression disease, we evaluated clinical, hormonal, radiological and pathological predictors of surgical outcome in acromegaly.Methods: A single-institution retrospective study from 2009 to 2015 was per...

Overt hyperthyroidism occurs in about 0.1–0.4% of all pregnancies. Propylthiouracil (PTU) is recommended in first trimester due to risk of teratogenicity with Carbimazole (CBZ). CBZ is preferable in rest of the pregnancy and postpartum period due to risk of serious liver disease with PTU. We reviewed our management of hyperthyroidism in pregnancy from 2009 to 2014. Total number of pregnancies =34, mean maternal age 32.6 years. Except one all (33/34) were diagnosed pre- pr...

Objective: The management of pituitary apoplexy, a rare emergency neuroendocrine condition, is controversial. The aim of the present study was to compare the outcome of patients with pituitary apoplexy managed either by a conservative or surgical approach.Methods: A retrospective cohort study including patients diagnosed between 2007 and 2018 in a tertiary French university hospital. Pituitary apoplexy score was retrospectively applied in a perspective o...

Background: Medical treatment of pituitary adenomas with somatostatin analogs depends on tumor type and somatostatin receptor expression. Using polyclonal antibodies, their immunohistochemical (IHC) detection gave conflicting results. Therefore, we studied the IHC expression of SSTR2A and SSTR5 using two specific MABs in five types of pituitary adenomas.Methods: SSTR2A and SSTR5 expression was studied using two...

Objective: Silent corticotroph adenomas (SCA) are rare pituitary tumours immunoreactive for ACTH but without clinical evidence of Cushing’s disease. They have been compared to non functioning pituitary adenomas or ACTH adenomas with Cushing’s disease, but no distinction has been made between micro and macro ACTH-adenomas. We characterize SCA on clinical, hormonal and molecular data and compared the characteristic of these tumours with those of macro (MCA) and micro A...

Background: Oncocytomas are predominantly benign tumors that are well described in the kidney, thyroid and salivary glands. They have also been reported in more rare sites including the pituitary and parathyroid glands, respiratory tract and choroid plexus. The occurrence of these tumors in the adrenal gland, however, represents an extremely exceptional finding.Case presentation: We report the case of a 34 year-old male patient who presented with a right...

Development in autologous bone marrrow transplantation (auto-BMT) has improved survival, but new endocrine complications now emerge. If primary thyroid and gonadal deficiencies are documented in medical literature, pituitary deficiencies are less well-known, especially in adults. The aim of the study was to investigate pituitary function in patients who survived at least one year after transplantation for malignant haematologic disorders by a prospective study.<p class="ab...

When pituitary MRI show a typical imaging of adenoma, it is agreed that transsphenoidal surgery is the reference treatment with remission achieved in about 80% of patients. If MRI is negative or inconclusive, some authors consider that the results of surgery are less successful, and propose medical treatment as a first line therapy, despite a disease control rate between 30 and 70%. Since 1990, our center chose to systematically explore patients with ACTH dependent hypercortic...